Resolve to Save Lives was created in 2017 by Dr. Tom Frieden, former director of the US Centers for Disease Control and Prevention (CDC). Through his work in government and with philanthropy, Dr. Frieden pinpointed a unique problem: no one is thinking about how to systematically combat the world’s leading killers. Heart disease carries the distinction of being the world’s #1 cause of death. And few organizations raise their focus from one disease to look at epidemics as a whole—and how they can be prevented. Resolve to Save Lives is committed to saving lives from these preventable causes by partnering with government and civil society to implement scalable, proven strategies. We prioritize partnerships with national and local organizations in low- and middle-income countries to co-create, advocate for, and scale up activities in heart disease prevention and epidemic preparedness. We work with global organizations to produce and promote policies that maximize health gains. Our funders include Bloomberg Philanthropies, the Bill & Melinda Gates Foundation and Gates Philanthropy Partners, which is funded with support from the Chan Zuckerberg Foundation. We are resolved to save lives.