KNCV Nigeria is firmly equipped with the technical and administrative capacity to strengthen TB, HIV/AIDS, and COVID-19 vaccination service delivery platforms, supporting health system strengthening and research in Nigeria. With 150 program staff in 14 state offices and over 2,000 ad hoc health care workers across 248 facilities, KNCN Nigeria has remained a major player in TB program implementation in Nigeria. We employ a systems approach, using data-driven quality improvement methods to identify and address gaps in TB and HIV diagnostic and management services. Our work focuses on collaborative planning, design, and implementation, engaging the private sector, strengthening service delivery platforms and community structures, and improving the quality of services available in Nigeria.